Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.
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1. TDP-43: Past, Present and Future
2. Structural studies of TDP-43
3. TDP-43 mutations and Amyotrophic Lateral Sclerosis
4. Post translational modifications of TDP-43
5. TDP-43 and Autophagy
6. TDP-43 and Alzheimer Disease
7. TDP-43 and Stress granules
8. Repeat domains in TDP-43
8. Systems Biology of TDP-43
9. Animal models of TDP-43 in ALS
10. Therapeutic modulations of TDP-43
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Comprehensive reference covering the fundamentals of TDP-43 structure, folding, function, pathology, pathomechanisms, and current and future therapeutics
Reviews TDP-43 structure, folding, function, and pathology
Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases
Presents a systems and precision biology perspective of TDP-43
Discusses therapeutics of TDP-43 proteinopathies
Translates bench research to application bedside
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Produktdetaljer
ISBN
9780128200667
Publisert
2021-10-27
Utgiver
Vendor
Academic Press Inc
Vekt
410 gr
Høyde
229 mm
Bredde
152 mm
Aldersnivå
P, UP, 06, 05
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
270
Redaktør